Conclusions: Ametop and EMLA topical anesthetic agents produce effective skin analgesia for venous cannulation. The use of topical analgesia can reduce perceived anxiety about future cannulation procedures. This has application in the management of anxious patients undergoing intravenous sedation, suggesting that topical analgesia prior to venous cannulation may significantly aid anxiolysis.

Speirs AF, Taylor KH, Joanes DN, Girdler NM. A randomized, double-blind, placebo-controlled, comparative study of topical skin analgesics and the anxiety and discomfort associated with venous cannulation. Br Dent J. 2001 Apr 28;190(8):444-9. doi: 10.1038/sj.bdj.4800999. PMID: 11352393.

https://pubmed.ncbi.nlm.nih.gov/11352393/

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